Edward Emerson, born in Chapel Hill, North Carolina in 1859 opened a pharmacy in Annapolis, Maryland in 1879 after graduating from the University of North Carolina. He moved to Baltimore in 1881 where he open ed three pharmacies. On January 15, 1889, he compounded a granular effervescent salt which he called Bro o-Seltzer, and trademarked it May 2, 1889. The formula for Brome-Seltzer in 1898 consisted of acetanilid, tartaric acid, sodium bicarbonate, potassium bromide and sugar. In 1891 Emerson withdrew from retail pharmacy and devoted full-time to manufacturing his proprietary, organizing the Emerson Drug Company. Attacked by Wiley's crusade, Emerson revised the formula to eliminate the objectionable acetanilid and Brome-Seltzer still remains a major seller in the market place today.
(Holcombe, Henry W., Weekly Philatelic Gossip, 24: 271-272, May 8, 1937)